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Contains ingredients shown to improve sleep and reduce vasomotor symptoms*

GABA is the primary inhibitory neurotransmitter in the brain, which means it plays a central role in balancing the excitability of neurons (1). Because of this reason, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5).

Serotonin is important for modifying the thermoregulatory set point (6). This means supporting serotonin may help to ameliorate hot flashes (7). Kavinace Flash-Ease contains 5-HTP (precursor to serotonin) and two botanicals with serotonergic activity (ashwagandha and black cohosh) (8,9).* Ashwagandha supports a healthy stress response, while black cohosh exhibits GABAergic and potentially selective estrogenic activity (8,10,11).* In a randomized, double-blind, placebo-controlled study, black cohosh significantly reduced vasomotor symptoms, improved sleep quality, and reduced wakefulness after falling asleep (12).*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References
1. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
2. Mohler H. Neuropharmacology. 2012;62(1):42-53.
3. Saper C, et al. Nature. 2005;437(7063):1257-63.
4. Mody I and Maguire J. Front Cell Neurosci. 2012;6:4.
5. Maguire J. Front Cell Neurosci. 2014;8:157.
6. Bruck K and Zeisberger E. Pharmacol Ther. 1987;35(1-2):163-215.
7. Freedman R. et al. Menopause. 2011;18(8):893-6.
8. Wuttke W, et al. J Steroid Biochem Mol Biol. 2014;139:302-10.
9. Kaurav B, et al. Asian Pac J Trop Med. 2012;5(5):380-4.
10. Auddy B, et al. J Am Neutraceut Assoc. 2008;11:50-56.
11. Jarry H, et al. Maturitas. 2003;44 Suppl 1:S31-8.
12. Jiang K, et al. Climacteric. 2015;18(4):559-67.

Supplement Facts
1 capsule contains:
Proprietary Blend 550mg
---4-amino-3-phenylbutyric acid HCl, Ashwagandha root extract (4.5% withanolides), 5-hydroxytryptophan (from Griffonia simplicifolia seed extract) and Black cohosh root extract (2.5% triterpene glycosides)
Other Ingredients: microcrystalline cellulose, vegetable capsule (hypromellose, water) and magnesium stearate (vegetable source).

Recommended Use:
Adults: Take 1 capsule at bedtime as needed or as recommended by a healthcare professional.

Warning:
Use under the supervision of a licensed healthcare practitioner. If you are pregnant or nursing, consult your health care practitioner before use. KEEP OUT OF THE REACH OF CHILDREN.

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