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Contains ingredients important for energy, managing musculoskeletal discomfort, and improving cognition*

Key ingredients
Synapsa@ (Bacopa monnieri whole plant extract): Bacopa monnieri demonstrates neuroprotective and adaptogenic effects, increases cerebral blood flow, and attenuates depletions in neurotransmitters in vivo (1-4).* In randomized, double-blind, placebo-controlled studies, Bacopa monnieri significantly improved working memory and energy levels, information processing, learning rate, and memory consolidation (5,6).*

L-tyrosine: Precursor to catecholamines including dopamine, norepinephrine, and epinephrine. Catecholamines released by the sympathetic nervous system regulate the stress response and downregulate immune activation (7,8).

Boswellia serrata (70% total boswellic acids): Leukotrienes are immune mediators that induce and sustain immune activation (9). Boswellic acids are shown to inhibit 5-lipoxygenase (5-LOX), an enzyme responsible for the synthesis of immunostimulatory molecules called leukotrienes (10,11).* In a randomized, double-blind, placebo-controlled, crossover study, Boswellia serrata significantly improved the threshold and tolerance to musculoskeletal discomfort (12).*

L-methionine: Precursor to S-adenosylmethionine (SAMe) (13). SAMe is directly involved in methylation processes including catecholamine synthesis (14).

Huperzia serrata aerial parts (1% huperzine A): Huperzine A slows the breakdown of acetylcholine by inhibiting acetylcholinesterase (AChE) (15).* Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system important for regulating the immune system, learning and memory (16,17).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References
1. Liu X, et al. Restor Neurol Neurosci. 2013;31(2):109-23.
2. Sheikh N, et al. J Ethnopharmacol. 2007;111(3):671-6.
3. Kamkaew N, et al. Phytother Res. 2013;27(1):135-8.
4. Rastogi M, et al. Biogerontology. 2012;13(2):183-95.
5. Stough C, et al. Phytother Res. 2008;22(12):1629-34.
6. Stough C, et al. Psychopharmacology (Berl). 2001;156(4):481-4.
7. Pongratz G and Straub R. Arthritis Res Ther. 2014;16:504.
8. Lee D, et al. BMB Rep. 2015;48(4):209-16.
9. Gennara A and Haeggstrom J. Adv Immunol. 2012;116:51-92.
10. Schweizer S, et al. J Nat Prod. 2000;63:1058-61.
11. Radmark O, et al. Biochim Biophys Acta. 2015;1851(4):331-9.
12. Prabhavathi K, et al. Indian J Pharmacol. 2014;46(5):475-9.
13. Duncan T, et al. Mol Nutr Food Res. 2013;57(4):628-36.
14. Mischoulon D and Fava M. Am J Clin Nutr. 2002;76(5):1158S-61S.
15. Tun M and Herzon S. J Exp Pharmacol. 2012;4:113-23.
16. Tracey K. Nat Rev Immunol. 2009;9(6):418-28.
17. Drever B, et al. Behav Brain Res. 2011;221(2):505-14.

Supplement Facts
2 capsules contain:
Proprietary Blend 1.2 g
---L-glutamic acid HCl, Bacopa monnieri whole plant extract, L-tyrosine, Boswellia serrata resin extract (70% total boswellic acids), L-methionine, Huperzine serrata aerial parts (1% huperzine A), Mucuana cochinchinensis seed extract (99% L-DOPA).
Other Ingredients: Vegetable capsule (hypromellose, water), microcrystalline cellulose, silicon dioxide and magnesium stearate (vegetable source).

Recommended Use:
Adults: Take 2 capsules up to 3 times daily or as recommended by a healthcare professional.

Warning:
If you are pregnant or nursing, consult your healthcare practitioner before use. Keep out of the reach of children.

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