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DHEA TR, 120 Vcaps, Nutra BioGenesis
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DHEA TR by BioGenesis is a natural supplement that provides dehydroepiandrosterone (DHEA) in a fiber-based time-release delivery system. DHEA is a metabolic precursor to other hormones and supports healthy adrenal glands and many other cells in the body.
  • DHEA supports healthy aging.*
  • May support healthy production and regulation of androgens, estrogens, cortisol*
  • DHEA provided in time-release delivery system
  • May support enhancing feelings of well-being*
  • May protect against cardiovascular dysfunction*
  • May support a healthy libido*
DHEA (or dehydroepiandrosterone) is a hormone produced by the adrenal gland and brain which serves as a precursor for all steroidal hormone production including both testosterone and estrogens. It is the bodys most abundant circulating steroid hormone, though the levels are generally higher in men than in women. Research has shown that levels peak at age 25 and markedly decline from there, with a decline of over 80% by age 70.*

DHEA TR is specifically formulated so that clinicians can prescribe a low amount of DHEA, and increase in small increments as necessary. The fiber-based time-release system allows the product to provide a stable amount of DHEA from which the body can use what it needs, thus avoiding cortisol surges or fluctuations in levels of androgens and estrogens. The time-release lasts anywhere from 6-12 hours, depending on transit time and digestive capabilities, and this allows for a normal circadian rhythm of both DHEA and cortisol. This should be dosed in the morning, as this is the when the adrenal glands usually release DHEA.*

REFERENCES:
1. Baylis D, Bartlett DB, Syddall HE, Ntani G, Gale CR, Cooper C, Lord JM, Sayer AA. Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people. Age (Dordr). 2012 Mar 3.
2. Creatsa M, Armeni E, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Alexandrou A, Dendrinos S, Augoulea A, Papamichael C, Lambrinoudaki I. Circulating androgen levels are associated with subclinical atherosclerosis and arterial stiffness in healthy recently menopausal women. Metabolism. 2012 Feb;61(2):193-201.
3. Dhatariya K, Bigelow ML, Nair KS. Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes. 2005 Mar;54(3):765-9.
4. Feldman HA, Johannes CB, McKinlay JB, Longcope C. Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study. Ann Epidemiol. 1998 May;8(4):217-28.
5. Genazzani AR, Stomati M, Valentino V, Pluchino N, Pot E, Casarosa E, Merlini S, Giannini A, Luisi M. Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality. Climacteric. 2011 Dec;14(6):661-8.
6. Haden ST, Glowacki J, Hurwitz S, Rosen C, LeBoff MS. Effects of age on serum dehydroepiandrosterone sulfate, IGF-I, and IL-6 levels in women. Calcif Tissue Int. 2000 Jun;66(6):414-8.
7. Hartaigh BO, Loerbroks A, Thomas GN, Engeland CG, Hollands MA, Fischer JE, Bosch JA. Age-dependent and -independent associations between depression, anxiety, DHEAS, and cortisol: From the MIPH Industrial Cohort Studies (MICS). Psychoneuroendocrinology. 2011 Nov 30.
8. Kenny AM, Boxer RS, Kleppinger A, Brindisi J, Feinn R, Burleson JA. Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women. J Am Geriatr Soc. 2010 Sep;58(9):1707-14.
9. Medina MC, Souza LC, Caperuto LC, Anh+¬ GF, Amanso AM, Teixeira VP, Bordin S, Carpinelli AR, Britto LR, Barbieri RL, Borella MI, Carvalho CR. Dehydroepiandrosterone increases beta-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats. FEBS Lett. 2006 Jan 9;580(1):285-90.
10. Nappi RE, Albani F, Santamaria V, Tonani S, Magri F, Martini E, Chiovato L, Polatti F. Hormonal and psycho-relational aspects of sexual function during menopausal transition and at early menopause. Maturitas. 2010 Sep;67(1):78-83.
11. Osmanagaoglu MA, Okumuş B, Osmanagaoglu T, Bozkaya H. The relationship between serum dehydroepiandrosterone sulfate concentration and bone mineral density, lipids, and hormone replacement therapy in premenopausal and postmenopausal women. J Womens Health (Larchmt). 2004 Nov;13(9):993-9.

Supplement Facts:
1 capsule contains:
DHEA (dehydroepiandrosterone) 10mg
Other Ingredients: rice flour, vegetable cellulose capsule, cellulose, silica.

Recommended Use:
Adults: As a dietary supplement, take 1 capsule up to two times per day or as recommended by a healthcare professional.

Warnings:
Anyone who currently has a hormone-related cancer, such as prostate, breast, or uterine cancers should not take DHEA as it can alter levels of sex hormones in the body. Also, those with liver disease should not take DHEA as it can generate free radicals in the liver during its conversion to DHEA-s. For patients without liver disease, taking an antioxidant formula such as Oxy Quench, can help protect the liver from free radical generation. If you are pregnant or nursing, please consult your healthcare professional before using this product. Keep out of the reach of children.

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